不同强度有氧运动对糖尿病大鼠肝脏炎症状态的影响.doc
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不同强度有氧运动对糖尿病大鼠肝脏炎症状态的影响
林文弢,李品芳,翁锡全摘要:为探讨不同强度有氧运动对糖尿病大鼠肝脏炎症状态的影响,为糖尿病的治疗提供新思路。通过高脂饲料喂养并注射链脲佐菌素的方法,建立SPF级雄性SD大鼠糖尿病模型,将造模成功后的43只大鼠随机分为:糖尿病安静对照组(DMC)10只,糖尿病运动1组(DME1)、糖尿病运动2组(DME2)、糖尿病运动3组(DME3)各11只。运动组大鼠分别在跑台上进行10、15和20 m/min的有氧运动,1 h/d,5 d/周,持续运动6周。实验第6周末检测糖代谢相关指标、血清与肝脏游离脂肪酸,以及反映炎症状态的肿瘤坏死因子(TNF-α),并对各指标进行Person相关性分析。结果发现:各运动组FBG均出现极显著性下降(P<0.01);DME1、DME2组GSP下降具有统计学意义(P<0.05、P<0.01);DME3组FINS的上升具有显著性意义(P<0.05),且DME1、DME2与DME3组间差异也存在显著性(P<0.05);DME1、DME2组IRI出现显著性下降(P0.05),并且显著性或极显著性高于DME1、DME2组(P<0.05、P<0.01);各运动组肝脏TNF-α均出现不同程度的下降,但只有DME2组具有统计学意义(P<0.01)。经Person相关性分析,肝脏TNF-α与FPG、IRI正相关。结果说明:6周的有氧运动能够降低糖尿病大鼠肝脏TNF-α含量,改善肝脏炎症状态,同时改善糖尿病大鼠的糖代谢紊乱和胰岛素抵抗,缓解糖尿病的发展。其中,中等强度有氧运动干预效果较好。
关键词:运动生物化学;糖尿病;肝脏炎症状态;肿瘤坏死因子-α;有氧运动;大鼠
中图分类号:G804.7文献标识码:A文章编号:1006-7116(2011)03-0136-04
Effect of different intensity exercise to liver inflammatory state of
rats with diabetic mellitus
LIN Wen-tao,LI Pin-fang,WENG Xi-quan
(Guangzhou Sport University,Guangzhou 510500,China)
Abstract: This study is to discuss the anti-inflammatory effect of different intensity exercise, providing new ideas for the treatment of diabetes. Rat model of diabetes were established by high-fat diet with low-dose streptozotocin intraperitoneally injected, and randomly divided into diabetes control group (DMC), and 3 exercising groups (DME1, DME2, DME3). After adapting to treadmill exercise, exercise groups underwent treadmill training at the speed of 10 m/min (DME1)、15 m/min(DME2)and 25 m/min(DME3), 1 h/d, 5 d/week, continuous training for 6 weeks. After 6 weeks, the histopathologic changes of livers were evaluated.the serum ALT, AST, the liver NF-κB content were tested. Results: The exercise group FBG were significant decrease (P<0.01); DME1, DME2 group of GSP decreased significantly (P<0.05, P<0.01); FINS was increase significantly in DME3 Group (P<0.05), and DME1, DME2 and DME3 group there was significant difference (P<0.05); DME1, DME2 group IRI were decreased (P0.05), and sig
林文弢,李品芳,翁锡全摘要:为探讨不同强度有氧运动对糖尿病大鼠肝脏炎症状态的影响,为糖尿病的治疗提供新思路。通过高脂饲料喂养并注射链脲佐菌素的方法,建立SPF级雄性SD大鼠糖尿病模型,将造模成功后的43只大鼠随机分为:糖尿病安静对照组(DMC)10只,糖尿病运动1组(DME1)、糖尿病运动2组(DME2)、糖尿病运动3组(DME3)各11只。运动组大鼠分别在跑台上进行10、15和20 m/min的有氧运动,1 h/d,5 d/周,持续运动6周。实验第6周末检测糖代谢相关指标、血清与肝脏游离脂肪酸,以及反映炎症状态的肿瘤坏死因子(TNF-α),并对各指标进行Person相关性分析。结果发现:各运动组FBG均出现极显著性下降(P<0.01);DME1、DME2组GSP下降具有统计学意义(P<0.05、P<0.01);DME3组FINS的上升具有显著性意义(P<0.05),且DME1、DME2与DME3组间差异也存在显著性(P<0.05);DME1、DME2组IRI出现显著性下降(P0.05),并且显著性或极显著性高于DME1、DME2组(P<0.05、P<0.01);各运动组肝脏TNF-α均出现不同程度的下降,但只有DME2组具有统计学意义(P<0.01)。经Person相关性分析,肝脏TNF-α与FPG、IRI正相关。结果说明:6周的有氧运动能够降低糖尿病大鼠肝脏TNF-α含量,改善肝脏炎症状态,同时改善糖尿病大鼠的糖代谢紊乱和胰岛素抵抗,缓解糖尿病的发展。其中,中等强度有氧运动干预效果较好。
关键词:运动生物化学;糖尿病;肝脏炎症状态;肿瘤坏死因子-α;有氧运动;大鼠
中图分类号:G804.7文献标识码:A文章编号:1006-7116(2011)03-0136-04
Effect of different intensity exercise to liver inflammatory state of
rats with diabetic mellitus
LIN Wen-tao,LI Pin-fang,WENG Xi-quan
(Guangzhou Sport University,Guangzhou 510500,China)
Abstract: This study is to discuss the anti-inflammatory effect of different intensity exercise, providing new ideas for the treatment of diabetes. Rat model of diabetes were established by high-fat diet with low-dose streptozotocin intraperitoneally injected, and randomly divided into diabetes control group (DMC), and 3 exercising groups (DME1, DME2, DME3). After adapting to treadmill exercise, exercise groups underwent treadmill training at the speed of 10 m/min (DME1)、15 m/min(DME2)and 25 m/min(DME3), 1 h/d, 5 d/week, continuous training for 6 weeks. After 6 weeks, the histopathologic changes of livers were evaluated.the serum ALT, AST, the liver NF-κB content were tested. Results: The exercise group FBG were significant decrease (P<0.01); DME1, DME2 group of GSP decreased significantly (P<0.05, P<0.01); FINS was increase significantly in DME3 Group (P<0.05), and DME1, DME2 and DME3 group there was significant difference (P<0.05); DME1, DME2 group IRI were decreased (P0.05), and sig
不同强度有氧运动对糖尿病大鼠肝脏炎症状态的影响
